Lele is Clinical Associate Professor at the Institute of Global Health and the MRC Clinical Trials Unit at University College London (UCL). She is also an honorary Associate Professor at her alma mater, University of Cape Town in South Africa.

She is an ID Clinician Scientist with 20 years of experience. Her research areas span the epidemiology of poverty-related diseases, randomized assessments of public health technology, digital health innovation and implementation science. Her team conducts clinical trials of TB prevention across multimorbidities, people at risk, and world regions. She holds a Wellcome Trust Investigator and EDCTP awards to conduct multi-country research on TB, NCD and TB prevention.

Lele sits on a number of international working groups including TB-LEAP, Collaboration for TB Vaccine Discovery (CTVD), the Cross-Network TB Vaccine Working Group (TB Vaccine WG), Maternal and Child Working Group of the Union, the LTBI Task Force of the StopTB New Diagnostic Working Group, and is a member of the Lancet Digital Health International Advisory Board and UCL-TB Leadership.